Large DNA deletions and rearrangements at both off-target and on-target sites

Large deletions and rearrangements of the plant’s genome, which can involve thousands of base units of DNA, have been observed following CRISPR gene editing.

The Dr. S. Biswas study found that CRISPR gene editing in rice varieties caused a wide range of undesirable and unintended on-target and off-target mutations.

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