Genomic rearrangement resulting from shattering of chromosomes (chromothripsis) at on-target gene editing sites

Michael Leibowitz talks about CRISPR gene editing for gene therapy applications can cause massive damage to chromosomes. The phenomenon is known as chromothripsis. The fact that the damage occurs “on-target” – at the intended edit site – means that any attempts to target the CRISPR gene editing more precisely will not solve this problem.

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