Creation of new gene sequences leads to new RNA and protein products

Alteration of the genetic code of the targeted gene can produce mutant forms of the protein it encodes for, new RNA, and new protein products. These outcomes can lead to changes in the plant’s biochemistry and the possible production of novel allergens and toxins.

Mou H CRISPR gene editing for gene therapy applications can cause massive damage to chromosomes. The phenomenon is known as chromothripsis. The fact that the damage occurs “on-target” – at the intended edit site – means that any attempts to target the CRISPR gene editing more precisely will not solve this problem.
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1237-8

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