Wikileaks: US Should Retaliate Against EU for Genetically Modified Resistance

IRT NEWS TEAM UPDATE: Jeffrey Smith talks to Democracy Now! about the U.S. diplomatic cables released by WikiLeaks which reveals that the Bush administration drew up ways to retaliate against Europe for refusing to use genetically modified seeds. Watch the interview.

2010-12-20-wikileaks.jpg“Country team Paris recommends that we calibrate a target retaliation list that causes some pain across the EU” [Emphasis added] –Recommendation by US Ambassador to France, Craig Stapleton.

Wikileaked cables released over the weekend revealed more about the US’ role as a global bully, trying to thrust unpopular genetically modified (GM) crops onto cautious governments and their citizens. In a 2007 cable from Craig Stapleton, then US Ambassador to France, he encouraged the US government to “reinforce our negotiating position with the EU on agricultural biotechnology by publishing a retaliation list.” A list, he added, that “causes some pain across the EU since this is a collective responsibility.”

The stated reason for their attack was that “Europe is moving backwards not forwards” on GMOs, with “France playing a leading role, along with Austria, Italy and even the [EU] Commission.” The Ambassador was concerned that France and others would put a ban on the cultivation of Monsanto’s GM corn seeds called Mon 810, engineered with a gene that produces a toxic insect-killing pesticide in every cell. Mon 810 is the first GM crop approved for planting EU-wide and has been a test case for biotech expansionism into the continent.

According to the cable, the Ambassador also rejected the France’s new “Grenelle” environment process, which looks beyond just the science of new technologies to also take into account “common interest.” Evidently a government that looks out for common interest is just too much for Ambassador Stapleton. He wrote, “Combined with the precautionary principle, this is a precedent with implications far beyond MON-810 BT corn cultivation.”

He was also upset about France’s draft biotech law that “would make farmers and seed companies legally liable for pollen drift.” This concept that the “polluter pays” is a foundational principle of US law–except for GMOs. Here Stapleton also wants France to give a free pass for Monsanto and the other GM seed companies.

The French government and EU Commission tried to placate the US suggesting that the rejections of Mon 810 “are only cultivation rather than import bans.” But Stapleton says, “We see the cultivation ban as a first step, at least by anti-GMO advocates, who will move next to ban or further restrict imports.”

The ambassador fails to point out that a de facto ban of GM ingredients in food has been in place since 1999, not by the government, but by the food industry. They have kept GMOs out of their products due to widespread consumer concern about the health effects. Since foods containing GMOs must be labeled in Europe, companies always source non-GMO food to avoid that label.

The exception is animal feed. EU law does not require meat or other animal products to label whether GMOs were fed to the animals. This loophole has allowed lots of US- and Brazil-grown GMO animal feed to be shipped to Europe. According to the cable, “The [French] environment minister’s top aide told us that people have a right not to buy meat raised on biotech feed.” Offering consumers a choice on GMOs is not on the US government agenda.

Ambassador Stapleton had been a co-owner with George W. Bush of the Texas Rangers baseball team. Once Bush was in office, Stapleton became US Ambassador to the Czech Republic, and then in France. His pro-GMO stance was in-line with the Bush administration, which used a WTO lawsuit to try to force Europe to accept GMOs.

Stapleton’s tone in the letter was insistent. “We should not be prepared to cede on cultivation because of our considerable planting seed business in Europe.”

He said, “Moving to retaliation will make clear that the current path has real costs to EU interests and could help strengthen European pro-biotech voices. In fact, the pro-biotech side in France — including within the farm union — have told us retaliation is the only way to begin to begin to turn this issue in France.”

Update:

  • France banned Mon 810 in early 2008. Several other EU nations have also banned it.
  • In 2009, the American Academy of Environmental Medicine stated that animal feeding studies on GMOs showed significant health disorders. They called on the US government to institute an immediate moratorium, and asked all doctors to prescribe non-GMO diets in the meantime.
  • This year, the major French retailer Carefour introduced a new “Reared without GMOs” label for meat raised on non-GMO feed.
  • The Non-GMO Shopping Guide released in the US lists thousands of products that do not use GM ingredients, either directly or via animal feed.

GE Salmon? Are You Out of Your Minds?!

No Frankenfish! Act Now

To help stop GE salmon, please sign petitions to the food industry and Congress.

Has the FDA gone completely mad? Why are they trying to open the flood gates to genetically engineered (GE) salmon—a move that will go down in history as one of the most asinine and dangerous ever made by our government? What’s it going to take for them to actually start protecting public health?

Frankenfish can promote disease

The FDA is reviewing data submitted by AquaBounty, the company that spliced a growth hormone gene into Atlantic salmon, forcing it to grow up to five times faster, and reach market size in about 18 months instead of 3 years. But according to the evidence, their buff salmon might have higher levels of a cancer promoting hormone IGF-1, more antibiotics, and more of a potentially life-threatening allergen(s).

The FDA failed to learn their lesson with their idiotic approval of genetically engineered bovine growth hormone. It also has higher levels of IGF-1 and more antibiotics. Now it’s condemned by the American Public Health Association and the American Nurses Association, banned in most other countries, and has been banished by most US dairies. Even Wal-Mart won’t allow the stuff into their milk.

The GE soy and corn on the market, which the FDA continues to pretend is just the same as the natural stuff, also has higher levels of allergens, and has been linked to numerous disorders. Now the American Academy of Environmental Medicine condemned genetically modified organisms (GMOs) and urged all physicians to prescribe non-GMO diets. “GMO-Free” is one of the fastest growing health claims among US brands for the past two years, and a tipping point of consumer rejection of all GE ingredients appears to be just over the horizon.

Then there is the threat of Frankenfish escaping into the wild. Here too, the FDA ignores the lessons from GE crops which, in spite of early assurances to the contrary, have been contaminating non-GE crops and wild relatives all over the world for more than a decade. Their self-propagating genetic pollution is irreversible; it can outlast the effects of global warming and nuclear waste. But somehow escaped GE salmon carry an even greater hazard.

Frankenfish can wipe out natural salmon

According to a Purdue University computer model that tracked the effects of releasing just 60 Frankenfish (not salmon) into a population of 60,000, there was a shocking complete extinction in just 40 fish generations. Apparently their bigger size, which attracted mates more easily, combined with a slight reduction in survival rates, was a killer combination.

Canadian scientists engineered their own set of fast growing salmon and tested their behavior in tanks with other fish. When there was sufficient food, all was fine. When food stocks decreased, the Frankenfish freaked. They became cannibals, attacking and killing other fish—whether GE or natural. Their unexpected behavior resulted in population crashes or complete extinctions in the fish tanks. The study also suggested that if released, these ravenous aggressive salmon would pursue and consume other types of fish.

I’m not sure which scenario is worse: The complete extinction of salmon, or gangs of voracious mutant freaks scouring the ocean, attacking anything that can feed their rapidly-expanding, always-hungry bodies. (Heck, let’s just give the fish automatic weapons.)

Never mind that the GE AquAdvantage salmon are supposed to be grown in inland tanks and are supposed to be sterile. In reality, they won’t all be sterile; and there are numerous ways that these salmon, whose eggs will regularly be shipped from Prince Edward Island, Canada to growing tanks in Panama, can escape into the ocean. It only takes one!

Corporate interests and politics run the FDA show

US consumers have been clear for years that we don’t want Frankenfish, Frankenpigs, Frankenmosquitoes, Frankenanything that walks, flies, slithers, or swims. And most Americans are now uneasy about the Frankencrops already growing in our fields. So who is clamoring for GE salmon? Who’s getting the FDA to push open the doors to GE animals against public opinion?

Thank you Union of Concerned Scientists for the answer. Your September 12th survey of 1710 FDA employees explains who is really driving the bus at the agency. One staff member said, “Food safety has succumbed to the higher priority of global corporate profits.” In fact, 38 percent of respondents agreed or strongly agreed that “public health has been harmed by agency practices that defer to business interests.”

Another employee points to political interference: “I have been here for 26 years and it still amazes me . . . how politics filter down to the lowest levels of government.”

So its corporate profits and politics. Anyone surprised? About 1 in 4 surveyed admit that they had personally experienced, either frequently or occasionally, “situations where corporate interests [or members of Congress, or special interests] have forced the withdrawal or significant modification of [an agency] policy or action designed to protect consumers or public health.”

If there is one face that best captures the FDA’s conflict-of-humanity’s-interest, it would be Michael Taylor. Taylor is the US Food Safety Czar. You’d think that if there were significant safety concerns about the GE salmon, our Czar would step in to preserve and protect. Don’t count on it.

Back when the first Bush White House had instructed the FDA to promote biotechnology, the agency created a special position for Taylor to be in charge. He had been the outside attorney for biotech giant Monsanto, where he had dreamed up a regulatory facade that would allow GMOs to be brought to market with maximum speed and minimum oversight. Then he took a position with the FDA where he could apparently implement it himself. His GMO policy falsely claimed that the agency was unaware of information showing GM foods to be different. On that basis, no testing or labeling was required. Years later, 44,000 documents made public from a lawsuit revealed that the consensus among FDA’s own scientists was that GM foods were unsafe, and should be carefully tested for allergies, toxins, new diseases, and nutritional problems.

Soon after leaving the FDA, Michael Taylor went to work as Monsanto’s vice president.

So the person who lied about GMO safety to push them on the market now sits above the folks that are looking at GE Salmon. Not a comforting thought.

Stacking the deck for approving salmon

How else does corporate influence play out in the current FDA debacle?

Consider Alison L. Van Eenennaam. She too used to work for Monsanto, and now has been added as a temporary voting member on the committee that advises the FDA about the salmon. She also advises the USDA and promotes GE animals on Youtube.

Kevin G. Wells was also added as a temporary voting member for salmon. He works at Revivicor, a company that genetically engineers pigs. Do you suppose there is any conflict of interest for him establishing an easy ride for GE animal approvals? Perhaps.

Gregory Jaffe was also imported into the committee as their supposed consumer advocate. In reality, he is with the pro-GMO Center for Science in the Public Interest (CSPI), an organization that consistently ignores the mounting evidence of adverse health impacts from GE crops. Jaffe even filed a complaint to the FDA in 2001 complaining of companies that label their products as non-GMO. What further qualified Jaffe for his committee position was his published article Questions About Genetically Engineered Animals, where he touts the environmental benefits of AquAdvantage salmon.

The engineered bias of the FDA advisory committee is made even more clear by who is absent. There are no experts on allergies or hormones who can address the possible health damaging effects of the fish, and no fish ecologists who can figure out whether our grandchildren will live in a world without wild salmon.

Institutionalized stupidity

But even before the committee was picked, the deck was stacked in favor of approvals. In 2008, the Bush administration rolled out a policy in which GE animals would be approved as if they were animal drugs. This latest square peg is part of a continuing effort to regulate GMOs without asking Congress to pass any new laws. So, since 1992, the government has been jerry-rigging inadequate pre-existing laws to handle the unique and complex safety and environmental considerations of genetically engineered organisms.

Even if GE animals weren’t infinitely more complex than some drug compound, using the FDA drug approval process shouldn’t give us great confidence. Between 1976 and 1985, for example, more than half of their drug approvals turned out to have lethal or serious side effects, forcing withdrawal or added label warnings. Try conducting a recall of GE salmon from the ocean.

Failing grades all around

Even with stacked committee membership, an antiquated approval policy, and an agency that is officially mandated to promote biotechnology, the Frankenfish did not swim past the advisory committee on September 19th and 20th. That’s because the committee agreed with safety experts like Dr. Michael Hansen of the Consumers Union (they publish Consumer Reports) that the evidence presented by AquaBounty was abysmal and insufficient. Using a sample size of only 6 fish, employing insensitive detection methods that could easily miss cancer-promoting hormones or allergens, and testing fish that were raised in a completely different climate than what is planned, were among the sloppy science that the FDA had accepted. (See addendum below for examples.)

In fact the only person on the committee who had any experience with fish, Gary Thorgaard, completely disagreed with the FDA’s conclusion that the Frankenfish didn’t threaten the environment. He called for a full Environmental Impact Statement.

Hansen says, “The data and analysis of food safety risks from the AquAdvantage Salmon are so sloppy and inadequate that, if this were an undergraduate paper, it would get a failing grade.  No self-respecting scientist could conclude that these data demonstrate that AquAdvantage salmon are safe to eat.”

Thus, in spite of the fact that the company had been submitting data to the FDA for more than ten years, the advisory committee concluded that the evidence was insufficient to conclude that GE salmon was safe for the environment and for human health. They told AquaBounty to go back and to do more testing.

I propose a different recommendation. This little exercise made it perfectly clear that AquaBounty is either completely incompetent to evaluate the safety of their own creation, or they’re intentionally hiding evidence. In either case, let’s not send the same folks back to do more research, hoping they’ll get it right. Instead, tell these jokers that they have proved to the world that they are never ever ever to be trusted with the future of salmon or the safety of the human food supply.

And what about the FDA—the brain cell behind the Don’t-ask-don’t-tell food safety assessments? They have again demonstrated that they too are not competent to protect the public from the unique unpredictable dangers of genetically engineered foods.

If you want to GE salmon stopped for good, now is the time to raise your voice. Since the FDA has been ignoring US citizens in favor of business interests and politics, please join me in inviting the food industry and Congress to stop in and stop this madness. Go to our action alert pages to sign the petitions today.

. . .

Addendum: How Not to Do a Food Safety Assessment

The FDA’s evaluation of GE salmon is the first of its kind. Because it will set a precedent for all future GE animal approvals, the bar should be set very high. According to Dr. Michael Hansen, who testified at the FDA advisory committee meeting on behalf of Consumers Union, the FDA set the bar a foot off the ground.

When AquaBounty looked for potentially dangerous growth hormones in the salmon, for example, they used a detection method so insensitive, it couldn’t find any hormones in any fish. The FDA therefore concluded that there was no relevant difference in hormone levels in GE salmon. Dr. Hansen told the committee, “This would be like the police using a radar gun that cannot detect speeds below 120 mph and concluding that there is no ‘relevant difference’ in the speed of cars versus bicycles.”

Because the company also used an insensitive test to measure cancer-promoting insulin-like growth hormone factor one (IGF-1), levels were detected in only a few fish. Of these, the GE salmon was 40% higher. Again, insufficient data combined with faulty reasoning allowed the FDA to conclude that IGF-1 from GE salmon is not a problem.

Even then, these test results were not from the type of GE salmon that the company plans to market. Instead, the tests were conducted on the GE salmon variety that will produce the fish eggs in Canada. The DNA of these “egg-layers” have the normal two sets of chromosomes (diploid). The GE salmon to be grown from their eggs in Panama, however, end up with three sets of chromosomes (triploid)—so that most will be sterile. It’s the Panama-grown triploid variety that will go onto our dinner table if the FDA has their way. So what was the response by the FDA and AquaBounty when asked for the IGF-1 levels of the actual fish (raised in the actual conditions) that people would actually eat? “Well…er….uhm…we’ll get back to you.”

The situation with allergies is worse. According to Hansen, the tests conducted by AquaBounty confirmed that “the act of genetic engineering did lead to an increase in allergenic potency.” In fact, when the flesh from egg-laying (diploid) fish was exposed to the blood (sera) of people who are allergic to salmon, there was a whopping 52% increase in reaction levels. Furthermore, the specific allergen that had increased in the Frankenfish was not supposed to be affected. It did not come from the inserted gene. Rather, the increase in this potentially life-threatening allergen was just one of the unpredictable side-effects that can result from the process of genetic engineering itself.

The FDA decided this time to ignore this troublesome finding, since it was from the egg-laying diploids. The company did test the allergic reaction to the triploids (the ones we’ll eat), but used fish that were raised in Canada, not Panama. This should have disqualified the fish study, according to Hansen, since the composition of GE salmon can obviously be affected by water temperature, and growing conditions. Still, the Canadian raised Frankenfish still elicited an allergic response level that was 20% higher than normal salmon. But the FDA dismissed this figure since it was not statistically significant and concluded that the GE salmon was safe to eat. But of course it wasn’t statistically significant. They used just six fish in the sample size! The easiest way to prevent statistical significance is by using a pathetically small number of subjects in your experiment. Hansen said:

“To base a conclusion of no additional risk on exactly six engineered fish, when those data themselves suggest a possible problem, is not responsible science or responsible risk assessment. FDA owes it to the thousands of Americans who are allergic to finfish to demand more data on the allergenicity of these engineered salmon from AquaBounty.”

Thank you Dr. Hansen for helping to protect us from the bungling Frankenfish promoters. Let’s hope they will listen.

Don’t forget to sign the petitions to the food industry and Congress.

International bestselling author and filmmaker Jeffrey M. Smith is the executive director of the Institute for Responsible Technology. His first book, Seeds of Deception: Exposing Industry and Government Lies About the Safety of the Genetically Engineered Foods You’re Eating, is the world’s bestselling and #1 rated book on GMOs. His second, Genetic Roulette: The Documented Health Risks of Genetically Engineered Foods, documents 65 health risks of the GM foods Americans eat every day. Both are distributed by Chelsea Green Publishing. To help you choose healthier, non-GMO brands, use the Non-GMO Shopping Guide.

Genetically Modified Foods: Toxins and Reproductive Failures

Rhetoric from Washington since the early 1990s proclaims that genetically modified (GM) foods are no different from their natural counterparts that have existed for centuries. But this is a political, not a scientific assertion. Numerous scientists at the FDA consistently described these newly introduced gene-spliced foods as cause for concern. In addition to their potential to produce hard-to-detect allergies and nutritional problems, the scientists said that "The possibility of unexpected, accidental changes in genetically engineered plants" might produce "unexpected high concentrations of plant toxicants."[1] GM crops, they said, might have "Increased levels of known naturally occurring toxins, . . . appearance of new, not previously identified" toxins, and an increased tendency to gather "toxic substances from the environment" such as "pesticides or heavy metals." They recommended testing every GM food "before it enters the marketplace."[2] But the FDA was under orders from the first Bush White House to promote the biotechnology industry, and the political appointee in charge of agency policy was Monsanto’s former attorney—later their vice president. The FDA policy ignored the scientists’ warnings and allowed GM food crops onto the market without any required safety studies.

From the few safety tests that have been conducted, the results are disturbing—lab animals fed GM diets show damage to virtually every system studied. Reports from farmers are even less encouraging—thousands of sick, sterile and dead animals are traced to GM feed.[3]

GM diet shows toxic reactions in digestive tract

The very first crop submitted to the FDA’s voluntary consultation process, the FlavrSavr tomato, showed evidence of toxins. Out of 20 female rats fed the GM tomato, 7 developed stomach lesions.[4] The director of FDA’s Office of Special Research Skills wrote that the tomatoes did not demonstrate a "reasonable certainty of no harm,"[5] which is their normal standard of safety. The Additives Evaluation Branch agreed that "unresolved questions still remain."[6] The political appointees, however, did not require that the tomato be withdrawn.[*]

According to Arpad Pusztai, PhD, one of the world’s leading experts in GM food safety assessments, the type of stomach lesions linked to the tomatoes "could lead to life-endangering hemorrhage, particularly in the elderly who use aspirin to prevent [blood clots]."[7] Pusztai believes that the digestive tract should be the first target of GM food risk assessment, because the gut is the first (and largest) point of contact with the foods; it can reveal various reactions to toxins. He was upset, however, that the research on the FlavrSavr never looked passed the stomach to the intestines. Other studies that did look found problems.

Mice were fed potatoes with an added bacterial gene, which produced an insecticide called Bt-toxin. Scientists analyzed the lower part of their small intestines (ileum) and found abnormal and damaged cells, as well as proliferative cell growth.[8] Rats fed potatoes engineered to produce a different type of insecticide (GNA lectin from the snowdrop plant) also showed proliferative cell growth in both the stomach and intestinal walls (see photo – click here for larger image).[9] Although the guts of rats fed GM peas were not examined for cell growth, the intestines were mysteriously heavier; possibly resulting from such growth.[10] Cell proliferation can be a precursor to cancer and is of special concern.

GM diets cause liver damage

The state of the liver—a main detoxifier for the body—is another indicator of toxins.

  • Rats fed the GNA lectin potatoes described above had smaller and partially atrophied livers.[11]
  • Rats fed Monsanto’s Mon 863 corn, engineered to produce Bt-toxin, had liver lesions and other indications of toxicity.[12]
  • Rabbits fed GM soy showed altered enzyme production in their livers as well as higher metabolic activity.[13]
  • The livers of rats fed Roundup Ready canola were 12%-16% heavier, possibly due to liver disease or inflammation.[14]
  • And microscopic analysis of the livers of mice fed Roundup Ready soybeans revealed altered gene expression and structural and functional changes.[15] Many of these changes reversed after the mice diet was switched to non-GM soy, indicating that GM soy was the culprit. The findings, according to molecular geneticist Michael Antoniou, PhD, "are not random and must reflect some ‘insult’ on the liver by the GM soy." Antoniou, who does human gene therapy research in King’s College London, said that although the long-term consequences of the GM soy diet are not known, it "could lead to liver damage and consequently general toxemia."[16]

Higher death rates and organ damage

Some studies showed higher death rates in GM-fed animals. In the FlavrSavr tomato study, for example, a note in the appendix indicated that 7 of 40 rats died within two weeks and were replaced.[17] In another study, chickens fed the herbicide tolerant "Liberty Link" corn died at twice the rate of those fed natural corn.[18] But in these two industry-funded studies, the deaths were dismissed without adequate explanation or follow-up.

In addition, the cells in the pancreas of mice fed Roundup Ready soy had profound changes and produced significantly less digestive enzymes;[19] in rats fed a GM potato, the pancreas was enlarged.[20] In various analyses of kidneys, GM-fed animals showed lesions, toxicity, altered enzyme production or inflammation. Enzyme production in the hearts of mice was altered by GM soy.[21] And GM potatoes caused slower growth in the brain of rats.[22]

Reproductive failures and infant mortality

In both mice and rats fed Roundup Ready soybeans, their testicles showed dramatic changes. In rats, the organs were dark blue instead of pink (see photo – click here for larger image).[23] In mice, young sperm cells were altered.[24] Embryos of GM soy-fed mice also showed temporary changes in their DNA function, compared to those whose parents were fed non-GM soy.[25]

More dramatic results were discovered by a leading scientist at the Russian National Academy of sciences. Female rats were fed GM soy, starting two weeks before they were mated.

  • Over a series of three experiments, 51.6 percent of the offspring from the GM-fed group died within the first three weeks, compared to 10 percent from the non-GM soy group, and 8.1 percent for non-soy controls.
  • "High pup mortality was characteristic of every litter from mothers fed the GM soy flour."[26]
  • The average size and weight of the GM-fed offspring was quite a bit smaller.[27]
  • In a preliminary study, the GM-fed offspring were unable to conceive.[28]

After the three feeding trials, the supplier of rat food used at the Russian laboratory began using GM soy in their formulation. Since all the rats housed at the facility were now eating GM soy, no non-GM fed controls were available for subsequent GM feeding trials; follow-up studies were canceled. After two months on the GM soy diet, however, the infant mortality rate of rats throughout the facility had skyrocketed to 55.3 percent (99 of 179).[29]

Farmers report livestock sterility and deaths

About two dozen farmers reported that thousands of their pigs had reproductive problems when fed certain varieties of Bt corn. Pigs were sterile, had false pregnancies, or gave birth to bags of water. Some cows and bulls also became sterile. Bt corn was also implicated by farmers in the deaths of cows, horses, water buffaloes, and chickens. [30]

When Indian shepherds let their sheep graze continuously on Bt cotton plants, within 5-7 days, one out of four sheep died. There was an estimated 10,000 sheep deaths in the region in 2006, with more reported in 2007. Post mortems on the sheep showed severe irritation and black patches in both intestines and liver (as well as enlarged bile ducts). Investigators said preliminary evidence "strongly suggests that the sheep mortality was due to a toxin. . . . most probably Bt-toxin."[31]

Dangerous denial

The warnings of the FDA scientists appear to have come true. But we were not supposed to know about their concerns. The agency’s internal memos were only made public due to a lawsuit. Instead, we were supposed to believe the official FDA policy, claiming that the agency is not aware of information showing that GM foods are meaningfully different. This statement, crafted by political appointees, directly contradicts the scientific consensus at the FDA.

Nearly every independent animal feeding safety study on GM foods shows adverse or unexplained effects. But we were not supposed to know about these problems either—the biotech industry works overtime to try to hide them. Industry studies described above, for example, are neither peer-reviewed nor published. It took lawsuits to make two of them available. And adverse findings by independent scientists are often suppressed, ignored, or denied. Moreover, researchers that discover problems from GM foods have been fired, stripped of responsibilities, deprived of tenure, and even threatened. The myth that GM crops are the same safe food we have always eaten continues to circulate.

With the overwhelming evidence of problems since their introduction in 1996, however, it is likely that GM foods are contributing to the deterioration of health in the United States. Without human clinical trials or post-marketing surveillance, we can’t tell which worsening health statistic may be due to these foods. But we also can’t afford to wait until we find out. GM foods must be removed from our diet immediately. Fortunately, more and more people are making healthy non-GM choices for themselves and their family. To learn which foods are genetically modified and how to protect yourself, visit the Non-GMO Shopping Guide.

[*] Calgene had submitted data on two lines of GM tomatoes, both using the same inserted gene. They voluntarily elected to market only the variety that was not associated with the lesions. This was not required by the FDA, which did not block approvals on the lesion-associated variety. The FlavrSavr tomato has since been taken off the market. After the FlavrSavr, no other biotech company has submitted such detailed data to the FDA. And the superficial summaries they do present to the agency are dismissed by critics as woefully inadequate to judge safety.

[1] Edwin J. Mathews, Ph.D., in a memorandum to the Toxicology Section of the Biotechnology Working Group. Subject: Analysis of the Major Plant Toxicants. Dated October 28, 1991.

[2] Division of Food Chemistry and Technology and Division of Contaminants Chemistry, "Points to Consider for Safety Evaluation of Genetically Modified Foods: Supplemental Information," November 1, 1991, www.biointegrity.org

[3] Jeffrey M. Smith, Genetic Roulette: The Documented Health Risks of Genetically Engineered Foods, Yes! Books, Fairfield, IA USA 2007

[4] Department of Veterinary Medicine, FDA, correspondence June 16, 1993. As quoted in Fred A. Hines, Memo to Dr. Linda Kahl. "Flavr Savr Tomato: . . . Pathology Branch’s Evaluation of Rats with Stomach Lesions From Three Four-Week Oral (Gavage) Toxicity Studies . . . and an Expert Panel’s Report," Alliance for Bio-Integrity (June 16, 1993) http://www.biointegrity.org/FDAdocs/17/view1.html

[5] Robert J. Scheuplein, Memo to the FDA Biotechnology Coordinator and others, "Response to Calgene Amended Petition," Alliance for Bio-Integrity (October 27, 1993) www.biointegrity.org

[6] Carl B. Johnson to Linda Kahl and others, "Flavr Savr™ Tomato: Significance of Pending DHEE Question," Alliance for Bio-Integrity (December 7, 1993) www.biointegrity.org

[7] Arpad Pusztai, "Genetically Modified Foods: Are They a Risk to Human/Animal Health?" June 2001 Action Bioscience www.actionbioscience.org/biotech/pusztai.html

[8] Nagui H. Fares, Adel K. El-Sayed, "Fine Structural Changes in the Ileum of Mice Fed on Endotoxin Treated Potatoes and Transgenic Potatoes," Natural Toxins 6, no. 6 (1998): 219-233.

[9] Stanley W. B. Ewen and Arpad Pusztai, "Effect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine," Lancet, 1999 Oct 16; 354 (9187): 1353-4.

[10] Arpad Pusztai, "Facts Behind the GM Pea Controversy: Epigenetics, Transgenic Plants & Risk Assessment," Proceedings of the Conference, December 1st 2005 (Frankfurtam Main, Germany: Literaturhaus, 2005).

[11] Arpad Pusztai, "Can science give us the tools for recognizing possible health risks of GM food," Nutrition and Health, 2002, Vol 16 Pp 73-84.

[12] John M. Burns, "13-Week Dietary Subchronic Comparison Study with MON 863 Corn in Rats Preceded by a 1-Week Baseline Food Consumption Determination with PMI Certified Rodent Diet #5002," December 17, 2002 www.monsanto.com/monsanto/content/sci_tech/prod_safety/fullratstudy.pdf

[13] R. Tudisco, P. Lombardi, F. Bovera, D. d’Angelo, M. I. Cutrignelli, V. Mastellone, V. Terzi, L. Avallone, F. Infascelli, "Genetically Modified Soya Bean in Rabbit Feeding: Detection of DNA Fragments and Evaluation of Metabolic Effects by Enzymatic Analysis," Animal Science 82 (2006): 193-199.

[14] Comments to ANZFA about Applications A346, A362 and A363 from the Food Legislation and Regulation Advisory Group (FLRAG) of the Public Health Association of Australia (PHAA) on behalf of the PHAA, "Food produced from glyphosate-tolerant canola line GT73," www.iher.org.au/

[15] M. Malatesta, C. Caporaloni, S. Gavaudan, M. B. Rocchi, S. Serafini, C. Tiberi, G. Gazzanelli, "Ultrastructural Morphometrical and Immunocytochemical Analyses of Hepatocyte Nuclei from Mice Fed on Genetically Modified Soybean," Cell Struct Funct. 27 (2002): 173-180.

[16] Jeffrey M. Smith, Genetic Roulette: The Documented Health Risks of Genetically Engineered Foods, Yes! Books,Fairfield, IA USA 2007

[17] Arpad Pusztai, "Can Science Give Us the Tools for Recognizing Possible Health Risks for GM Food?" Nutrition and Health 16 (2002): 73-84.

[18] S. Leeson, "The Effect of Glufosinate Resistant Corn on Growth of Male Broiler Chickens," Department of Animal and Poultry Sciences, University of Guelph, Report No. A56379, July 12, 1996.

[19] Malatesta, et al, "Ultrastructural Analysis of Pancreatic Acinar Cells from Mice Fed on Genetically modified Soybean," J Anat. 2002 November; 201(5): 409-415; see also M. Malatesta, M. Biggiogera, E. Manuali, M. B. L. Rocchi, B. Baldelli, G. Gazzanelli, "Fine Structural Analyses of Pancreatic Acinar Cell Nuclei from Mice Fed on GM Soybean," Eur J Histochem 47 (2003): 385-388.

[20] Arpad Pusztai, "Can science give us the tools for recognizing possible health risks of GM food," Nutrition and Health, 2002, Vol 16 Pp 73-84.

[21] R. Tudisco, P. Lombardi, F. Bovera, D. d’Angelo, M. I. Cutrignelli, V. Mastellone, V. Terzi, L. Avallone, F. Infascelli, "Genetically Modified Soya Bean in Rabbit Feeding: Detection of DNA Fragments and Evaluation of Metabolic Effects by Enzymatic Analysis," Animal Science 82 (2006): 193-199.

[22] Arpad Pusztai, "Can science give us the tools for recognizing possible health risks of GM food," Nutrition and Health, 2002, Vol 16 Pp 73-84.

[23] Irina Ermakova, "Experimental Evidence of GMO Hazards," Presentation at Scientists for a GM Free Europe, EU Parliament, Brussels, June 12, 2007.

[24] L. Vecchio et al, "Ultrastructural Analysis of Testes from Mice Fed on Genetically Modified Soybean," European Journal of Histochemistry 48, no. 4 (Oct-Dec 2004):449-454.

[25] Oliveri et al., "Temporary Depression of Transcription in Mouse Pre-implantion Embryos from Mice Fed on Genetically Modified Soybean," 48th Symposium of the Society for Histochemistry, Lake Maggiore (Italy), September 7-10, 2006.

[26] I.V.Ermakova, "Genetically Modified Organisms and Biological Risks," Proceedings of International Disaster Reduction Conference (IDRC) Davos, Switzerland August 27th – September 1st, 2006: 168-172.

[27] Irina Ermakova, "Genetically modified soy leads to the decrease of weight and high mortality of rat pups of the first generation. Preliminary studies," Ecosinform 1 (2006): 4-9.

[28] Irina Ermakova, "Experimental Evidence of GMO Hazards," Presentation at Scientists for a GM Free Europe, EU Parliament, Brussels, June 12, 2007.

[29] I.V.Ermakova "GMO: Life itself intervened into the experiments," Letter, EcosInform N2 (2006): 3-4.

[30] Jeffrey M. Smith, Genetic Roulette: The Documented Health Risks of Genetically Engineered Foods, Yes! Books, Fairfield, IA USA 2007.

[31] "Mortality in Sheep Flocks after Grazing on Bt Cotton Fields—Warangal District, Andhra Pradesh" Report of the Preliminary Assessment, April 2006, http://www.gmwatch.org/archive2.asp